Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations
نویسندگان
چکیده
منابع مشابه
Family members as gamete donors and surrogates.
1. Use of family members as donors or surrogates is generally ethically acceptable. 2. Brothers may donate sperm to brothers and sisters may donate eggs to sisters. 3. Intergenerational gamete donation and surrogacy are especially challenging. 4. Consanguineous gamete donations from first-degree relatives are unacceptable. 5. Counseling is encouraged for all parties including partners of donors...
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چکیده ندارد.
Biomarkers, putative surrogates, surrogates, and decision making.
T he development of new therapies is slow, expensive, and frustrating. The failure rate for new molecular entities exceeds 90%, and total research and development costs per successful new molecular entity are currently estimated to be nearly $2 billion. 1 Consternation about the complexity of therapeutic development recently prompted a major report by the President's Council of Advisors on Scie...
متن کاملComparing biomarkers as trial level general surrogates.
An intermediate response measure that accurately predicts efficacy in a new setting can reduce trial cost and time to product licensure. In this article, we define a trial level general surrogate, which is an intermediate response that can be used to accurately predict efficacy in a new setting. Methods for evaluating general surrogates have been developed previously. Many methods in the litera...
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PURPOSE Ovarian cancer has a high recurrence and mortality rate. A barrier to improved outcomes includes a lack of accurate models for preclinical testing of novel therapeutics. EXPERIMENTAL DESIGN Clinically relevant, patient-derived tumorgraft models were generated from sequential patients and the first 168 engrafted models are described. Fresh ovarian, primary peritoneal, and fallopian tub...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2020
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.201911896